Endocrine Abstracts

Introduction: Vitamin D insufficiency (D-INSUFF) has been associated with impaired immune response in human inmunodeficiency virus (HIV) patients and a worse prognosis in patients with liver fibrosis. Nevertheless, few studies have explored the influence of D-INSUFF in immunological response and liver parameters in HIV and hepatitis C virus co-infected patients (HIV/HCV) on long term highly active antiretroviral therapy (HAART) with successful immune and virological response. ...

Introduction: Although the importance of disorders in glucose metabolism is well recognized in human immunodeficiency virus (HIV) infected patients; the clinical relevance of prediabetes in this population has been little studied. The aims of this observational study were to determine the prevalence of prediabetes in a cohort of HIV-infected patients on long term highly active antiretroviral therapy (HAART) and to assess whether this condition involves the appearance of partic...

Introduction: Vitamin D deficiency is common among people living with HIV worldwide. There is a lack of studies focusing on prevalence and consequences of low levels of vitamin D in our health care area (south of Spain). The main aim of this study is to know the status of vitamin D and its consequences on parameters related to calcium metabolism in a cohort of patients with HIV infection in our area.Methods/Design: Cross-sectional study encompassing HIV-...

Introduction: Several studies have shown that BMI and visceral adiposity index (VAI) are inversely related to serum 25-hydroxy vitamin D (25OHD) in general population. There is a lack of studies performed in HIV population, whose body fat distribution is altered by lipodystrophy or liver disease. We aimed to analyze the cross-sectional associations of VAI and BMI with the 25OHD concentration and parameters related to calcium-phosphorus metabolism in HIV-infected patients.<...

Introduction: 25-Hydroxyvitamin D (25(OH)D) deficiency is a growing healthcare problem in HIV-infected patients. Evidence suggests that an optimal level of 25(OH)D would avoid secondary hyperparathyroidism but its optimal serum concentration has not been defined in HIV-infection. The aim of our study was to identify the 25(OH)D serum concentration that correlates to i-PTH increase and describe the prevalence of hypovitaminosis D in a cohort of HIV-infected patients.<p clas...

Rationale: Low level of vitamin D can results in secondary hyperparathyroidism (SH) that has been linked to increased cardiovascular risk in general population. However, the spectrum of cardiovascular risk associated with SH in HIV-infected adults remains uncertain. Our main aim was to determine its potential association with different markers of cardiovascular risk in HIV-infected adults.Methods: Cross-sectional study. Clinical data related to obesity, ...

Rationale: Type 2 diabetes mellitus (T2DM) is a well known independent prognosis factor associated with cirrhosis. Nevertheless, few studies are focused on the association between glucose metabolism and liver fibrosis in HCV/HIV patients and their conclusions are contradictory. The aim of our study was to investigate the relationship between glucose homeostasis and liver fibrosis in these patients.Methods: In a cross-sectional study, we compared prevalen...